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FLASH GENE
Symbol PDK3 contributors: npt/ - updated : 05-05-2006
HGNC name pyruvate dehydrogenase kinase, isoenzyme 3
HGNC id 8811
Location Xp22.11      Physical location : 24.483.343 - 24.568.582
Synonym name
  • pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
  • pyruvate dehydrogenase kinase isoform 3
  • EC.number 2.7.11.2
    DNA
    TYPE functioning gene
    STRUCTURE 74.61 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CNK2 Xp22.13 similar to H326 FLJ34960 Xp22.13 hypothetical protein FLJ34960 SMPX Xp22.1 small muscle protein, X-linked MBTPS2 Xp22.1-p22.2 membrane-bound transcription factor protease, site 2 SMS Xp22.1 spermine synthase PHEX Xp22.2-p22.1 phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) FLJ25735 Xp22.13 hypothetical protein FLJ25735 LOC389841 X LOC389841 DDX53 Xp22 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 MGC45134 Xp22.13 hypothetical protein MGC45134 LOC392432 X similar to hypothetical protein MGC35083 FLJ30296 Xp22.13 hypothetical protein FLJ30296 PRDX4 Xp22.12-p21.3 peroxiredoxin 4 ACATE2 Xp22.13 likely ortholog of mouse acyl-Coenzyme A thioesterase 2, mitochondrial SAT Xp22.1 spermidine/spermine N1-acetyltransferase MGC4825 Xp22.13 hypothetical protein MGC4825 LOC317771 Xp22.1 ribosomal protein L9 pseudogene FLJ25444 Xp22.13 hypothetical protein FLJ25444 KIAA1677 Xp22.1-p21 KIAA1677 EIF2S3 Xp22.2-p22.1 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa ZFX Xp22.13-p22.12 zinc finger protein, X-linked LOC347438 Xp22.13 similar to P38IP protein LOC170067 Xp22.13 similar to transcription factor (p38 interacting protein) LOC286513 Xp22.13 similar to 40S ribosomal protein S26 PDK3 Xp22,12 pyruvate dehydrogenase kinase, isoenzyme 3 PCYT1B Xp22.12 phosphate cytidylyltransferase 1, choline, beta isoform POLA Xp22.12 polymerase (DNA directed), alpha ARX Xp22.12 aristaless related homeobox LOC139957 Xp22.12 similar to platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa; platelet-activating factor acetylhydrolase, isoform Ib, beta subunit (30kD); Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit LOC220895 Xp22.12 similar to methyltransferase-like protein 1 isoform a; D1075-like gene product LOC389842 X similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) MGC33889 Xp22.12 hypothetical protein MGC33889 LOC392433 X similar to melanoma antigen, family B, 6 MAGEB6 Xp22.11 similar to melanoma antigen, family B, 6 LOC347541 Xp22.12 similar to melanoma antigen 2 VENTX2P1 Xp22.12 VENT-like homeobox 2 pseudogene 1 LOC347543 Xp22.11 similar to 60S ribosomal protein L7 HMGA1L1 Xp22 high mobility group AT-hook 1-like 1 LOC139420 Xp22.11 similar to KIAA1387 protein RDXP2 Xp22.12 radixin pseudogene 2 FLJ32742 Xp22.11 hypothetical protein FLJ32742 LOC347442 Xp22.11 similar to H326
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 12795 - 415 - -
    11 - 1803 - 406 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • histidine-kinase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • PDK/BCKDK protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • with PDK2 and PDK4 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS