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FLASH GENE
Symbol RELT contributors: mct - updated : 22-10-2019
HGNC name RELT tumor necrosis factor receptor
HGNC id 13764
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one TNFR-Cys repeat
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tnfrsf19l (86pc)
    homolog to murine Tnfrsf19l
    intraspecies homolog to TNFRSSF19
    homolog to RELL1 and RELL2
    Homologene
    FAMILY TNF receptor family
    CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • type 1 transmembrane protein
    • basic FUNCTION
  • activating the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1
  • stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response
  • induces apoptosis by a pathway distinct from other death-inducing TNFRs such as TNFR1
  • acts as a negative regulator that controls the early phase of T-cell activation probably by promoting T-cell apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding TRAF1
  • RELL1 and RELL2 are two newly identified RELT homologues that bind to the TNF receptor family member RELT
  • PLSCR1 physically interact with all known RELT family members
  • RELT family members physically interact with PLSCR1, and these interactions may regulate the phosphorylation of PLSCR1 by OXSR1
  • ADAM10 is expressed by ameloblasts, cleaves the RELT TNF receptor extracellular domain and facilitates enamel development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AI3C
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS