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FLASH GENE

Symbol

RELT

contributors: mct - updated : 22-10-2019

HGNC name	RELT tumor necrosis factor receptor
HGNC id	13764

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Homo sapiens   spleen       highly Homo sapiens Nervous brain         Homo sapiens Reproductive female system breast       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one TNFR-Cys repeat

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Tnfrsf19l (86pc)
	homolog to murine Tnfrsf19l

intraspecies	homolog to TNFRSSF19
	homolog to RELL1 and RELL2

Homologene

FAMILY

TNF receptor family

CATEGORY

regulatory , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
text	type 1 transmembrane protein

basic FUNCTION	activating the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1
	stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response
	induces apoptosis by a pathway distinct from other death-inducing TNFRs such as TNFR1
	acts as a negative regulator that controls the early phase of T-cell activation probably by promoting T-cell apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding TRAF1
	RELL1 and RELL2 are two newly identified RELT homologues that bind to the TNF receptor family member RELT
	PLSCR1 physically interact with all known RELT family members
	RELT family members physically interact with PLSCR1, and these interactions may regulate the phosphorylation of PLSCR1 by OXSR1
	ADAM10 is expressed by ameloblasts, cleaves the RELT TNF receptor extracellular domain and facilitates enamel development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AI3C

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS