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FLASH GENE
Symbol PACSIN3 contributors: mct/npt - updated : 26-09-2017
HGNC name protein kinase C and casein kinase substrate in neurons 3
HGNC id 8572
Location 11p11.2      Physical location : 47.199.073 - 47.208.010
Synonym name
  • SH3 domain-containing protein 6511
  • syndapin III
  • endophilin I
    • Synonym symbol(s) SDPIII, FLJ17861
    DNA
    TYPE functioning gene
    STRUCTURE 8.94 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1894 - 424 - 2012 22573331
    11 - 1913 - 424 - 2012 22573331
    11 - 2046 - 424 - 2012 22573331
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal gland    
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cdc 15 domain
  • one FES/CIP4 homology domain
  • one central coiled coil domain
  • a F-BAR domain
  • a SH3 domain at the C terminus, involved in interaction with TRPV4 (requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of the channel and the C-terminal Src homology 3 domain) (Cuajungco 2006), SH3 domain-mediated autoregulation of the membrane-deforming activity of F-BAR domains that is of crucial importance for its function (Rao 2010)
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pacsin 3
    Homologene
    FAMILY
  • PACSIN family
  • Fer-CIP4 homology-BAR (F-BAR) family
    • CATEGORY adaptor , signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text functional interaction with TRPV4 could be important in cell types that show distribution of both proteins to the same subcellular regions such as renal tubule cells where the proteins are associated with the luminal plasma membrane (Cuajungco 2006)
    basic FUNCTION
  • playing a role in vesicle formation and transport
  • may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation
  • in addition to a crucial role in endocytic internalization, complexes with EHDs play an important role in endocytic receptor recycling
  • acting as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner
  • function in dynamic microtubuli nucleation
  • intracellular adapter protein involved in vesicle transport, membrane dynamics and actin reorganisation
  • participate in cellular membrane trafficking, in regulation of dynamin-mediated endocytotic processes and have been shown to generate membrane tubules (Wang 2009)
  • novel function for PACSIN1, PACSIN2, PACSIN3 in dynamic microtubuli nucleation
  • wedge loop of PACSIN3 is more rigid as PACSIN1, PACSIN2, which influences the lateral interactions between assembled dimers
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with EHD1, EHD2
  • components of the centrosome involved in microtubule dynamics
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 zinc ion per subunit
    • protein
  • ADAM15
  • binding ADAM12( its proline-rich region required for binding)
  • specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization of the ion channel (Cuajungco 2006)
  • role for PACSIN3 in regulating glucose uptake in adipocytes via its preferential participation in SLC2A1 trafficking
  • exists in a persistent colocalized state with DNM1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS