basic FUNCTION
| playing a role in vesicle formation and transport |
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may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation |
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in addition to a crucial role in endocytic internalization, complexes with EHDs play an important role in endocytic receptor recycling |
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acting as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner |
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function in dynamic microtubuli nucleation  |
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intracellular adapter protein involved in vesicle transport, membrane dynamics and actin reorganisation  |
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participate in cellular membrane trafficking, in regulation of dynamin-mediated endocytotic processes and have been shown to generate membrane tubules (Wang 2009) |
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novel function for PACSIN1, PACSIN2, PACSIN3 in dynamic microtubuli nucleation  |
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wedge loop of PACSIN3 is more rigid as PACSIN1, PACSIN2, which influences the lateral interactions between assembled dimers  |