SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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| colocalizing with RPA heterotrimeric ss DNA binding protein in meiotic prophase nuclei of spermatocytes division, cell cycle, M, prophase |
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colocalizing transitorily with RPA, PML in nuclear bodies |
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present in replication fork |
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in mitotic cells, BLM and RMI2 were mostly present in the nucleoplasm  |
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BLM is expressed only in dividing cells; it is absent or greatly reduced in quiescent stem cells or in terminally differentiated non-dividing cell |
| basic FUNCTION
| DNA helicase, ATP-dependent, atypical and highly DNA structure specific, unwinding single and double strand DNA in a 3'->5' direction, promoting an ATP-dependent branch migration of Holliday junctions |
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putatively suppressor of homologous recombination between closely opposed and replicating strands, and selected target during the execution of apoptosis |
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playing a role in recombination-mediated telomere lengthening |
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DNA damage sensor signaling the formation of DNA damage induced foci |
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playing a conserved role in recovery from perturbations in DNA replication and likely RecQ helicases act to restore productive DNA replication following S-phase arrest and hence prevent subsequent genomic instability |
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playing a role in chromosome segregation in addition to its function during DNA replication and repair |
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involved in the promotion of single-stranded DNA (ssDNA) annealing |
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functioning in dissociating alternative DNA structures during recombination and/or replication at telomeric ends |
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with TOP3A execute the dissolution of sister chromatids |
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might be involved in both early and late steps of homologous recombination |
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might regress replication forks as part of a genome maintenance pathway |
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having an anti-recombination role |
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involved in disruption of the Rad51-ssDNA (single-stranded DNA) filament, an active species that promotes homologous recombination, and stimulation of DNA repair synthesis |
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playing a a role with EXO1 in the initiation of recombinational DNA repair |
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stimulating DNA strand exchange activity of RAD51 without ATP hydrolysis |
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functions as a Holliday junction dissolvase |
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role in the maintenance of gene cluster genomic integrity |
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performs double-stranded DNA unwinding by fully active duplex destabilization |
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regulates several steps of homologous recombination (HR)-dependent repair of double-strand DNA breaks |
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appears to be a master regulator that is needed by INSL6 as well as by the TOP3/RMI complex to execute diverse functions in order to maintain normal replication and genome stability |
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BRIP1 catalytic activity and its effect on BLM protein stability contribute to preservation of genomic stability and a normal response to replication stress |
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WRN and BLM are critical for maintaining genomic stability and thought to function in accurate resolution of replication blockage |
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ERCC6L and BLM decorate ultrafine histone-negative DNA threads that link the segregating sister centromeres during anaphase |
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ERCC6L and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution |
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BLM and RECQL4 have coordinated activities that promote genome stability |
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ERCC6L and BLM were required for the correct recruitment to the centromere of active TOP2A, an enzyme specialized in the catenation/decatenation process |
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BLM and ERCC6L cooperate in rendering centromeric catenates accessible to TOP2A, thereby facilitating correct centromere disjunction and preventing the formation of supernumerary centromeric ultrafine anaphase bridges |
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maintains genome integrity, at least in part, by suppressing illegitimate recombination events |
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mediates a checkpoint response to stabilize the replication machinery at stalled forks, thereby preventing replisome dissociation and an irreversible fork collapse |
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possible roles of BLM helicase in the recombination-mediated mechanism of telomere elongation |
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BLM promotes DNA end resection as part of the BLM-TOP3A-RMI1-RMI2 complex |
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BLM functions in 2 distinct pathways requiring different modifications: BLM functions to suppress SCE formation and in a second pathway, its phosphorylations are essential for suppression of chromosomal radial formation |
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BLM helicase has pivotal functions at the crossroads of DNA replication, recombination, and repair |
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FANCM and BLM complex work together at stalled forks to promote both Fanconi anemia repair and replication traverse pathways of interstrand crosslinks (ICLs) |
