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FLASH GENE

Symbol

CCL2

contributors: mct/ - updated : 27-01-2017

HGNC name	chemokine (C-C motif) ligand 2
HGNC id	10618

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Mcp1 -/- mice synthesized extremely low levels of interleukin-4, interleukin-5, and interleukin-10
	in Gjb1-deficient mice (Cx32def), Ccl2 is upregulated in a MEK–ERK-dependent manner (CCL2 reduction is a promising strategy to treat CMT1 neuropathies, particularly in disease forms where axon damage is predominant as in Cx32def mice and the corresponding human disorder, CMT1X)
	macrophages from Ccr2-null mice were not capable of promoting trans-endothelial migration of tumour cells