Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBP1 contributors: mct/npt - updated : 12-12-2009
HGNC name upstream binding protein 1 (LBP-1a)
HGNC id 12507
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Lbp1
homolog to Drosophila Elf1/ntf1
intraspecies homolog to TFCP2
Homologene
FAMILY
  • grh/CP2 family
  • CP2 subfamily
    • CATEGORY immunity/defense , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • represses class switch recombination in an isotype-specific manner via direct interaction with switch regions involved in the recombination (Repetny 2009)
  • plays a role in cholesterol and steroid metabolism via the transcriptional activation of CYP11A, the rate-limiting enzyme in pregnenolone and aldosterone biosynthesis (Koutnikova 2009)
  • with its functional partners are components of a network controlling blood pressure (Koutnikova 2009)
  • role at the internalization step of endocytosis or with enhanced recycling to the cell surface from an internal compartment (Schmitz 2005)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription corepressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility blood pressure modifications
    Variant & Polymorphism SNP rs17030583 C/T and rs2291897 G/A associated with blood pressure modifications (koutnikova 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS