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FLASH GENE

Symbol

UBP1

contributors: mct/npt - updated : 12-12-2009

HGNC name	upstream binding protein 1 (LBP-1a)
HGNC id	12507

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 3 encode the same isoform

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001128160 15 - 4054 NP_001121632 56.3 504 localized in the nucleus Sato (2005), Koutnikova (2009) LBP-1b peptide of 36 amino acids encoded by exon 6, a specific exon used only for LBP-1b, possessed the function of a nuclear localization signal (NLS) NM_001128161 17 - 3781 NP_001121633 60.4 540 exclusively localized in the cytosol Sato (2005), Koutnikova (2009) LBP-1a activity of LBP-1a for accumulation in the PML body was mapped in the N-terminal region NM_014517 16 - 4162 NP_055332 60.4 540 in the cytosol Sato (2009), Koutnikova (2009) LBP-1a activity of LBP-1a for accumulation in the PML body was mapped in the N-terminal region

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Lbp1
	homolog to Drosophila Elf1/ntf1

intraspecies

homolog to TFCP2

Homologene

FAMILY	grh/CP2 family
	CP2 subfamily

CATEGORY

immunity/defense , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	represses class switch recombination in an isotype-specific manner via direct interaction with switch regions involved in the recombination (Repetny 2009)
	plays a role in cholesterol and steroid metabolism via the transcriptional activation of CYP11A, the rate-limiting enzyme in pregnenolone and aldosterone biosynthesis (Koutnikova 2009)
	with its functional partners are components of a network controlling blood pressure (Koutnikova 2009)
	role at the internalization step of endocytosis or with enhanced recycling to the cell surface from an internal compartment (Schmitz 2005)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	transcription corepressor

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

blood pressure modifications

Variant & Polymorphism SNP	rs17030583 C/T and rs2291897 G/A associated with blood pressure modifications (koutnikova 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS