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FLASH GENE
Symbol UBP1 contributors: mct/npt - updated : 12-12-2009
HGNC name upstream binding protein 1 (LBP-1a)
HGNC id 12507
Location 3p22.2      Physical location : 33.429.830 - 33.481.897
Synonym name leader-binding protein-1a
Synonym symbol(s) LBP1A, LBP1B, NF2D9, LBP1, DKFZp686L1745
DNA
TYPE functioning gene
STRUCTURE 52.04 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text Variants 1 and 3 encode the same isoform
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 4054 56.3 504 localized in the nucleus Sato (2005), Koutnikova (2009)
  • LBP-1b
  • peptide of 36 amino acids encoded by exon 6, a specific exon used only for LBP-1b, possessed the function of a nuclear localization signal (NLS)
    • 17 - 3781 60.4 540 exclusively localized in the cytosol Sato (2005), Koutnikova (2009)
  • LBP-1a
  • activity of LBP-1a for accumulation in the PML body was mapped in the N-terminal region
    • 16 - 4162 60.4 540 in the cytosol Sato (2009), Koutnikova (2009)
  • LBP-1a
  • activity of LBP-1a for accumulation in the PML body was mapped in the N-terminal region
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Lbp1
    homolog to Drosophila Elf1/ntf1
    intraspecies homolog to TFCP2
    Homologene
    FAMILY
  • grh/CP2 family
  • CP2 subfamily
    • CATEGORY immunity/defense , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • represses class switch recombination in an isotype-specific manner via direct interaction with switch regions involved in the recombination (Repetny 2009)
  • plays a role in cholesterol and steroid metabolism via the transcriptional activation of CYP11A, the rate-limiting enzyme in pregnenolone and aldosterone biosynthesis (Koutnikova 2009)
  • with its functional partners are components of a network controlling blood pressure (Koutnikova 2009)
  • role at the internalization step of endocytosis or with enhanced recycling to the cell surface from an internal compartment (Schmitz 2005)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription corepressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility blood pressure modifications
    Variant & Polymorphism SNP rs17030583 C/T and rs2291897 G/A associated with blood pressure modifications (koutnikova 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS