SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,nucleus
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| text
| integral transmembrane protein, localizing to membrane lipid rafts |
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lysosomal protein trafficked in synapses through the ER-Golgi intermediary compartment ERGIC |
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in lysosomes in non-neuronal cells and in endosomes in neuronal cells. |
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localized in synaptosomes but not targetted to synaptic vesicles |
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predominantly a lysosomal protein |
| basic FUNCTION
| palmitoyl-protein Delta-9 desaturase, which converts membrane-associated palmitoylated proteins to their respective palmitoylated derivatives |
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potentially protecting neurons from apoptosis mediated by ceramide |
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chaperone involved in the folding/unfolding or assembly/disassembly of other proteins, regulating cell growth and apoptosis |
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multimembrane-spanning protein involved in recycling of synaptic vesicles through the endosomal lysosome |
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inhibitor of amyloid beta protein precursor and cathepsin |
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a N terminus probably involved in protein-protein interactions and a C terminal required for movement from ER to Golgi and prenylation |
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may have a role in regulating intracellular levels of arginine possibly through control of the transport of this amino acid into lysosomes |
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playing a role in neuronal proteolipid trafficking and synaptic transmission |
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negatively regulating cellular level of calsenilin, suppressing neuronal cell death mediated by calsenilin and dysregulation of intracellular Ca2+ |
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involved in the regulation of plasma membrane fodrin cytoskeleton and consequently, the plasma membrane association of Na(+), K(+) ATPase (ATP1B1) |
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may traffic across the cells from the Golgi apparatus to plasma membranes via endosomes/lysosomes or synaptosomes in neuronal cells |
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mediates several regulatory pathways by coupling the cell-cycle progression in G1 to physiological conditions, including nitrogen deprivation, daughter cell G1-delay and changes in glucose levels |
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may be involved in the cellular response to stress |
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specific role for CLN3 in the oxidative stress response, suggesting that a compromise of this response may be a fundamental defect leading to neurodegeneration in Batten disease |
