basic FUNCTION
| palmitoyl-protein Delta-9 desaturase, which converts membrane-associated palmitoylated proteins to their respective palmitoylated derivatives |
|
potentially protecting neurons from apoptosis mediated by ceramide |
|
chaperone involved in the folding/unfolding or assembly/disassembly of other proteins, regulating cell growth and apoptosis |
|
multimembrane-spanning protein involved in recycling of synaptic vesicles through the endosomal lysosome |
|
inhibitor of amyloid beta protein precursor and cathepsin |
|
a N terminus probably involved in protein-protein interactions and a C terminal required for movement from ER to Golgi and prenylation |
|
may have a role in regulating intracellular levels of arginine possibly through control of the transport of this amino acid into lysosomes |
|
playing a role in neuronal proteolipid trafficking and synaptic transmission |
|
negatively regulating cellular level of calsenilin, suppressing neuronal cell death mediated by calsenilin and dysregulation of intracellular Ca2+ |
|
involved in the regulation of plasma membrane fodrin cytoskeleton and consequently, the plasma membrane association of Na(+), K(+) ATPase (ATP1B1) |
|
may traffic across the cells from the Golgi apparatus to plasma membranes via endosomes/lysosomes or synaptosomes in neuronal cells |
|
mediates several regulatory pathways by coupling the cell-cycle progression in G1 to physiological conditions, including nitrogen deprivation, daughter cell G1-delay and changes in glucose levels  |
|
may be involved in the cellular response to stress  |
|
specific role for CLN3 in the oxidative stress response, suggesting that a compromise of this response may be a fundamental defect leading to neurodegeneration in Batten disease  |