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FLASH GENE
Symbol IRX1 contributors: mct - updated : 03-11-2010
HGNC name iroquois homeobox 1
HGNC id 14358
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • homeodomain and a hexapeptide-like motif
    • HOMOLOGY
    interspecies homolog to murine Irx1
    homolog to C.elegans C06e4.2
    Homologene
    FAMILY
  • TALE/IRO homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiples roles during pattern formation of vertebrate embryos
  • with IRX3, are required for proper formation of the intermediate renal tubule
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BDKRB2, FGF7 and HIST2H2BE are direct IRX1 targets
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    up-regulated in germ cells seminomas
    tumoral     --low  
    by hypermethylation in head and neck squamous cell carcinoma
    tumoral   LOH    
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could potentially serve as a biomarker for gastric cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-vasculogenic mimicry mechanisms, in addition to previously found cell growth and invasion
    ANIMAL & CELL MODELS