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FLASH GENE
Symbol IRX6 contributors: mct - updated : 03-10-2018
HGNC name iroquois homeobox protein 6
HGNC id 14675
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
homeodomain and a hexapeptide-like motif
HOMOLOGY
Homologene
FAMILY
  • tale family of homeobox proteins
  • Iroquois homeodomain transcription factor family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiples roles during pattern formation of vertebrate embryos
  • IRX6 is a key regulator of type 3a bipolar cell identity that prevents these cells from adopting characteristic features of type 2 bipolar cells
  • IRX6 is required downstream of bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • is likely required for the correct axon stratification of HCN4-expressing cells within the OFF sublamina of the inner plexiform layer
  • VSX1 has likely a partial inhibitory effect on the expression of IRX6
  • IRX6 can activate or repress transcription through Iroquois-binding sites found proximal to RCVRN, VSX1 and TACR3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to anterior/middle hypospadias
    Variant & Polymorphism SNP rs6499755 of IRX6 showed an association with susceptibility to anterior/middle hypospadias
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS