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FLASH GENE
Symbol IRX6 contributors: mct - updated : 03-10-2018
HGNC name iroquois homeobox protein 6
HGNC id 14675
Location 16q12.2      Physical location : 55.358.470 - 55.364.671
Synonym name
  • iroquois homeobox protein 7
  • homeodomain protein IRXB3
    • Synonym symbol(s) IRX7, IRX-3, IRXB3
    DNA
    TYPE functioning gene
    STRUCTURE 7.01 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located close to IRX3 and IRX5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2337 - 446 - 2001 11435706
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualbipolar cell Homo sapiens
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		homeodomain and a hexapeptide-like motif
    HOMOLOGY
    Homologene
    FAMILY
  • tale family of homeobox proteins
  • Iroquois homeodomain transcription factor family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing multiples roles during pattern formation of vertebrate embryos
  • IRX6 is a key regulator of type 3a bipolar cell identity that prevents these cells from adopting characteristic features of type 2 bipolar cells
  • IRX6 is required downstream of bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • is likely required for the correct axon stratification of HCN4-expressing cells within the OFF sublamina of the inner plexiform layer
  • VSX1 has likely a partial inhibitory effect on the expression of IRX6
  • IRX6 can activate or repress transcription through Iroquois-binding sites found proximal to RCVRN, VSX1 and TACR3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to anterior/middle hypospadias
    Variant & Polymorphism SNP rs6499755 of IRX6 showed an association with susceptibility to anterior/middle hypospadias
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS