Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACVR1C contributors: mct/npt - updated : 15/10/2008
HGNC name activin A receptor, type IC
HGNC id 18123
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 aa signal peptide
  • a cysteine-rich extracellular region
  • a GS domain
  • a cytoplasmic serine/threonine kinase domain
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Acvr1c (92.7 pc)
    homolog to murine Acvr1c (95.9 pc)
    intraspecies paralog to nodal
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • transforming growth factor beta subfamily
    • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • acting as a serine/threonine protein kinase
  • being a receptor for activin AB, activin B and NODAL
  • playing a role in cell differentiation, growth arrest and apoptosis
    • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text regulation of apoptosis
    PATHWAY
    metabolism
    signaling signal transduction
    signaling through MADH2 after activation by NODAL
    a component
  • forming a stable complex with type II receptor after ligand binding
  • complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • Mg2+
  • Mn2+
  • ATP
    • protein
  • binding the type 2 receptor protein ACVR2A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS