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FLASH GENE
Symbol GTF2A1 contributors: mct - updated : 16-10-2010
HGNC name general transcription factor IIA, 1, 19/37kDa
HGNC id 4646
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
isoforms Precursor . the alpha and beta subunits are postranslationally produced from the precursor form
HOMOLOGY
interspecies homolog to murine Gtf2a1
homolog to C.elegans K11D12.2
Homologene
FAMILY
  • TFIIA subunit 1 family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional activation via TBP and the TFIID complex
  • may regulate the intracellular molecular state and the function of TBPL1 through its property of binding to TBPL1
  • induces a conformational change within the TBP/TATA complex that enhances its stability
  • acting early during preinitiation complex formation
  • role in transcriptional activation
  • collaborating with TERF2IP, transduces activating intramolecular signals within the TBP coactivator complex that ultimately can lead to pre-initiation complex formation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha subunit of RNA polymerase II transcription factor II
  • heterodimer of an alpha (p35), a beta (p19) and a gamma subunit (p12)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBP (TATA-binding protein)
  • TFIID complex
  • substrate of taspase 1 (TASP1) as reported for the trithorax group mixed-lineage leukemia protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • excellent candidate biomarker for detectinge ovarian carcinoma
    • Therapy target
    ANIMAL & CELL MODELS