Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GTF2A1 contributors: mct - updated : 16-10-2010
HGNC name general transcription factor IIA, 1, 19/37kDa
HGNC id 4646
Location 14q31.1      Physical location : 81.646.393 - 81.687.575
Synonym name
  • glucose regulated protein, 58kD pseudogene
  • TFIIA alpha, p55
  • transcription initiation factor TFIIA 42 kDa subunit
    • Synonym symbol(s) TFIIA, TFIIA-42, TFIIAL, MGC129969, MGC129970, TF2A1
    DNA
    TYPE functioning gene
    STRUCTURE 41.20 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 initiation site 1358 - 337 - 1995 7724559
    also called TFIIA-37
    9 initiation site 1736 41.5 376 - 1995 7724559
    also called TFIIA-42
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    isoforms Precursor . the alpha and beta subunits are postranslationally produced from the precursor form
    HOMOLOGY
    interspecies homolog to murine Gtf2a1
    homolog to C.elegans K11D12.2
    Homologene
    FAMILY
  • TFIIA subunit 1 family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional activation via TBP and the TFIID complex
  • may regulate the intracellular molecular state and the function of TBPL1 through its property of binding to TBPL1
  • induces a conformational change within the TBP/TATA complex that enhances its stability
  • acting early during preinitiation complex formation
  • role in transcriptional activation
  • collaborating with TERF2IP, transduces activating intramolecular signals within the TBP coactivator complex that ultimately can lead to pre-initiation complex formation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha subunit of RNA polymerase II transcription factor II
  • heterodimer of an alpha (p35), a beta (p19) and a gamma subunit (p12)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBP (TATA-binding protein)
  • TFIID complex
  • substrate of taspase 1 (TASP1) as reported for the trithorax group mixed-lineage leukemia protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • excellent candidate biomarker for detectinge ovarian carcinoma
    • Therapy target
    ANIMAL & CELL MODELS