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FLASH GENE
Symbol FICD contributors: mct - updated : 25-06-2025
HGNC name FIC domain containing
HGNC id 18416
Corresponding disease
SPG92 spastic paraplegia 92, autosomal recessive
Location 12q23.3      Physical location : 108.909.050 - 108.913.380
Synonym name
  • huntingtin interacting protein E
  • fic S-phase protein cell division homolog (E. coli)
  • huntingtin-interacting protein 13
    • Synonym symbol(s) MGC5623, UNQ3041, HYPE, HIP13, SPG92
    EC.number 2.7.7.108
    DNA
    TYPE functioning gene
    STRUCTURE 5.93 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3255 52 458 - 2021 34408154
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     parathyroid    
     thyroid    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a WW domain
  • TPR-motifs that bind specifically to the conserved hydrophobic linker of HSPA5 and thus mediate specificity for the domain-docked conformation of HSPA5
    • HOMOLOGY
    interspecies ortholog to murine D5Ertd40e
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • FICD has a specific function in the regulation of protein stress responses
  • FICD may regulate the transition from neural progenitors to neurons
  • is an emerging drug target fine-tuning stress signaling in the endoplasmic reticulum (ER)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • normal and mutant huntingtin (HD)
  • FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone HSPA5
  • HSPA5 is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD
  • FICD is a bifunctional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation) from the ER-resident chaperone HSPA5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG92
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS