Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BRF2 contributors: mct - updated : 13-02-2014
HGNC name BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
HGNC id 17298
DNA
TYPE functioning gene
STRUCTURE 6.01 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1978 46.4 419 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae BRF
Homologene
FAMILY
  • TFIIB family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • factor exclusively required for transcription of the polII-type SnRNA genes
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TATA-binding protein (TBP)
    • cell & other
    REGULATION
    Other recruitment to the TATA box of the polII type SnRNA promoters is TBP-dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation of BRF1 and BRF2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells
    tumoral     --over  
    of ZNF703, ERLIN2, PROSC, GPR124, and BRF2 in urothelial carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS