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FLASH GENE
Symbol BRF1 contributors: mct - updated : 22-01-2013
HGNC name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
HGNC id 11551
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zinc finger motif
HOMOLOGY
Homologene
FAMILY
  • TFIIB family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • tRNA 5S,rRNA and virus associated (VA) RNA transcription
  • posttranscriptionally regulates mRNA levels by targeting AU-rich element-bearing transcripts to the decay machinery
  • involved in AU-rich element-mediated mRNA decay (AMD)
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of RNA polymerase III transcription factor TFIIIB,forming a stable complex with casein kinase 2
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • TBP (TATA-binding protein)
  • MAPKAPK2 inhibits BRF1-dependent AU-rich element mRNA decay through direct phosphorylation
  • HNRNPF is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
    • cell & other
    REGULATION
    Phosphorylated by MAPK-activated protein kinase 2 (MAPKAPK2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation of BRF1 and BRF2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chronic alcohol administration in mice leads to enhanced expression of Tbp, Brf1, tRNA, and 5S rRNA gene transcription in the liver