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FLASH GENE
Symbol BRF1 contributors: mct - updated : 22-01-2013
HGNC name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
HGNC id 11551
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
zinc finger motif
HOMOLOGY
Homologene
FAMILY
  • TFIIB family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • tRNA 5S,rRNA and virus associated (VA) RNA transcription
  • posttranscriptionally regulates mRNA levels by targeting AU-rich element-bearing transcripts to the decay machinery
  • involved in AU-rich element-mediated mRNA decay (AMD)
    • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of RNA polymerase III transcription factor TFIIIB,forming a stable complex with casein kinase 2
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • TBP (TATA-binding protein)
  • MAPKAPK2 inhibits BRF1-dependent AU-rich element mRNA decay through direct phosphorylation
  • HNRNPF is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
    • cell & other
    REGULATION
    Phosphorylated by MAPK-activated protein kinase 2 (MAPKAPK2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation of BRF1 and BRF2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chronic alcohol administration in mice leads to enhanced expression of Tbp, Brf1, tRNA, and 5S rRNA gene transcription in the liver