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FLASH GENE
Symbol BRF1 contributors: mct - updated : 22-01-2013
HGNC name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
HGNC id 11551
Location 14q32.33      Physical location : 105.675.622 - 105.767.329
Synonym name
  • general transcription factor IIIB, 90kD subunit
  • TBP - associated factor, RNA polymerase III, 90kD
  • TATA box binding protein (TBP)-associated factor 3C
  • TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
  • Synonym symbol(s) BRF, GTF3B, TAF3C, TAF3B2, TF3B90, TAFIII90
    DNA
    TYPE functioning gene
    STRUCTURE 106.29 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 3677 73.8 677 - 2000 10921893
  • involved in the transcription of tRNA adenovirus VA1,7SL and 5S RNA
  • containing a high mobility group protein 2 (HMG2)-related region in the highly charged C terminal half of the protein and a sequence related to GTF2B in the N terminus
  • - splicing 2057 - 134 - 2000 10921893
    required for transcription of the U6 promoter
    14 splicing 3585 - 473 - 2000 10921893
    18 splicing 3452 - 584 - 2000 10921893
    18 - 3386 - 562 - 2000 10921893
    17 - 3596 - 650 - 2000 10921893
    13 - 2876 - 439 - 2000 10921893
    - - 1170 - 208 - 2000 10921893
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    zinc finger motif
    HOMOLOGY
    Homologene
    FAMILY
  • TFIIB family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • tRNA 5S,rRNA and virus associated (VA) RNA transcription
  • posttranscriptionally regulates mRNA levels by targeting AU-rich element-bearing transcripts to the decay machinery
  • involved in AU-rich element-mediated mRNA decay (AMD)
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of RNA polymerase III transcription factor TFIIIB,forming a stable complex with casein kinase 2
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • TBP (TATA-binding protein)
  • MAPKAPK2 inhibits BRF1-dependent AU-rich element mRNA decay through direct phosphorylation
  • HNRNPF is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
  • cell & other
    REGULATION
    Phosphorylated by MAPK-activated protein kinase 2 (MAPKAPK2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation of BRF1 and BRF2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chronic alcohol administration in mice leads to enhanced expression of Tbp, Brf1, tRNA, and 5S rRNA gene transcription in the liver