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FLASH GENE
Symbol GTF3C5 contributors: KTN - updated : 06-12-2007
HGNC name general transcription factor IIIC, polypeptide 5, 63kDa
HGNC id 4668
Location 9q34      Physical location : 135.906.061 - 135.933.888
Synonym symbol(s) TFIIIC63, TFIIIC2-63, FLJ20857, TFIIICepsilon
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2380 59 519 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveesophagus   moderately
 mouthtongue  moderately
 stomach   moderately
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
 thymus   predominantly
Nervousbrain   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • a C terminal acidic region
  • secondary structure
  • a central helix-turn-helix motif
  • HOMOLOGY
    interspecies homolog to dog GTF3C5 (87.6 pc)
    homolog to rattus Gtf3c5 (84.1 pc)
    homolog to murine Gtf3c5 (85.4 pc)
    homolog to chicken GTF3C5 (74.8 pc)
    Homologene
    FAMILY
  • GTF3C family
  • TFIIIC subunit 5 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the recruitement of both TFIIIB and RNA polymerase III
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text
  • 5S class rRNA transcription
  • tRNA transcription from RNA polymerase III promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • part of the TFIIIC subcomplex TFIIIC2, consisting of five subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4 and GTF3C5
  • INTERACTION
    DNA binding
    RNA binding to tRNA and virus-associated RNA promoters
    small molecule
    protein
  • BRF1/GTF3B
  • GTF3C3
  • RPC62
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS