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FLASH GENE
Symbol GTF3C4 contributors: KTN - updated : 06-12-2007
HGNC name general transcription factor IIIC, polypeptide 4, 90kDa
HGNC id 4667
Location 9q34.13      Physical location : 135.545.727 - 135.565.468
Synonym symbol(s) TFIII90,TFIIIC2-90, KAT12, FLJ21002, TFIIIC90, MGC138450, TFIIICdelta
EC.number 2.3.1.48
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3866 91 822 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveesophagus   moderately
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  predominantly
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential zinc finger motif at the C terminus
  • conjugated PhosphoP
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to dog GTF3C4 (95 pc)
    homolog to chimpanzee GTF3C4 (96.5 pc)
    homolog to murine Gtf3c4 (92.8 pc)
    Homologene
    FAMILY
  • GTF3C family
  • TFIIIC subunit 4 family
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in recruitement of both TFIIIB and RNA polymerase III
  • acting as an H3 histone specific acetyltransferase
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text
  • 5S class rRNA transcription
  • tRNA transcription from RNA polymerase III promoter
  • transcription initiation from RNA polymerase III promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • part of the TFIIIC subcomplex TFIIIC2, consisting of five subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4 and GTF3C5
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with GTF3B/BRF1
  • interacting with GTF3C1
  • interacting with GTF3C2
  • interacting with GTF3C5
  • interacting with POLR3F/RPC39
  • interacting with POLR3C/RPC62
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS