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FLASH GENE

Symbol

GTF3C2

contributors: KTN - updated : 04-12-2007

HGNC name	general transcription factor IIIC, polypeptide 2, beta 110kDa
HGNC id	4665

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p23.3      Physical location : 27.548.720 - 27.579.868
Synonym symbol(s)	KIAA0011,TFIIIC-beta, TFIIIC110

DNA

TYPE	functioning gene
STRUCTURE	31.00 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 20 splicing 3935 100 911 - - variant 2 19 splicing 3859 100 911 - -

EXPRESSION

Type

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive intestine large intestine colon   moderately   intestine small intestine     lowly   liver       lowly Endocrine pancreas       lowly Lymphoid/Immune spleen       lowly   thymus       lowly Nervous brain       lowly Reproductive female system ovary     moderately   male system testis     lowly   male system prostate     lowly Respiratory lung       moderately Urinary kidney       specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, umbilial cord

PROTEIN

PHYSICAL PROPERTIES		acid ,basic
STRUCTURE

motifs/domains	four WD 40 repeats (TRP-ASP domains)
	stretches of acidic and basic regions

secondary structure

potential acidic and basic helices

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to dog GTF3C2 (93.7 pc)
	homolog to rattus Gtf3c2 (89.2 pc)
	homolog to murine Gtf3c2 (89 pc)

Homologene

FAMILY

GTF3C family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs and adenoviral VA genes
	initiating transcription complex assembly on tRNA
	may play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, initiation

PHYSIOLOGICAL PROCESS

text	control of cell proliferation

PATHWAY

metabolism

signaling

a component	beta subunit of the RNA polymerase III transcription factor TFIIIC
	specific of TFIIIC2a

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS