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FLASH GENE
Symbol FXR2 contributors: npt/mct - updated : 27-09-2017
HGNC name fragile X mental retardation, autosomal homolog 2
HGNC id 4024
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two K homology (KH) domain, and KH2 domains bind kissing complex RNA ligands with the same affinity as the FMR1 KH2 domain although other KH domains do not (Darnell 2009)
  • one RGG motif
  • a nuclear localization signal (NLS)
  • a nuclear export signal (NES)
  • putative RNA-binding domains
  • a C terminal stretch of basic aminoacids ressembling to nucleolar targeting signal
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Fxr2h
    intraspecies paralog to FXR1, FMR1 (see symbols) (Coffee 2010)
    Homologene
    FAMILY
  • FMR1 family
    • CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text shuttling between cytoplasm and nucleolus
    basic FUNCTION
  • RNA transport and regulation
  • may have a role in the development of fragile X mental retardation syndrome
  • required for the presence of behavioral circadian rhythms and this role may be relevant to the behavioral alterations observed in fragile X patients
  • differential regulation of zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus stem cells by FXR2 may be a key component of the mechanism that governs the different neurogenic processes in these two adult germinal zones
  • FXR2 is important for neuronal dendritic development
  • important roles for FXR2 and GRIA1 in neuronal development, and functional convergence between fragile X proteins in this neuronal development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nucleocytoplasmic transport
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing and heterodimerizing with FXR1 and FMR1
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • a nuclear localization signals of FXR1 and also FXR2 with tandem Tudor domain architectures, closely resembling that of UHRF1, which is proposed to bind methylated histone H3K9
  • RNA-binding protein FXR2 specifically regulates dentate gyrus (DG) of the hippocampus neurogenesis by reducing the stability of NOG mRNA
  • FMR1 and FXR2 additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GRIA1, but via distinct mechanisms
  • coordinated regulation of DLG4 mRNA by FMR1 and FXR2 that ultimately affects its fine-tuning during synaptic activity.
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS