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FLASH GENE
Symbol CD248 contributors: mct/npt - updated : 22-04-2010
HGNC name CD248 molecule, endosialin
HGNC id 18219
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal cancer
tumoral     --over  
in highly invasive glioblastoma multiforme, anaplastic astrocytomas, and metastatic carcinomas
constitutional        
silencing in fibroblasts strongly inhibited migration and proliferation (Christian 2008)
tumoral     --over  
observed in many cancers of various tissue origin, including colon, breast, pancreatic, and lung (Tomkowicz 2007)
tumoral        
led to an increase in small immature blood vessels and decreased numbers of medium and large tumor vessels (Tomkowicz 2007)
tumoral     --over  
in primary and metastatic human brain tumors, where it localized primarily to the tumor vasculature and a subset of tumor stromal cells (Carson-Walter 2009)
Susceptibility
Variant & Polymorphism
Candidate gene
  • marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells (Christian 2008)
  • Marker
    Therapy target
  • cellular localization of TEM1/endosialin and its expression profile in primary and metastatic brain tumors support efforts to therapeutically target this protein, potentially via antibody mediated drug delivery strategies (Carson-Walter 2009)
  • ANIMAL & CELL MODELS