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FLASH GENE
Symbol ARL6IP2 contributors: mct/npt - updated : 10-07-2008
HGNC name ADP-ribosylation factor-like 6 interacting protein 2
HGNC id 24047
Location 2p22.3      Physical location : -
Synonym name
  • atlastin 2
  • likely ortholog of mouse, ADP ribosylation like factor 6 interacting protein 2
  • ARL-6-interacting protein 2
  • Synonym symbol(s) ATL2, FLJ23293, ARL3IP2
    DNA
    TYPE functioning gene
    STRUCTURE 81.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2279 66.2 579 - Gorry (unpublished), Ingley (1999)
    - splicing - 66.2 583 - Gorry (unpublished)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly
    Endocrinepancreas   moderately
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
     spinal cord   highly
    Reproductivemale systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal domain
  • guanylate binding protein
  • ATP/GTP-binding site motif A (P-loop)
  • ring-type zinc finger
  • N- and C-termini facing the cytoplasm
  • conjugated HemoP
    HOMOLOGY
    interspecies ortholog to murine Arl6
    Homologene
    FAMILY
  • GBP family, atlastin family of GTPases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    text localize prominently to ER membranes along microtubules
    basic FUNCTION
  • GTPase functioning prominently in both ER and Golgi morphogenesis, but they do not appear to be required generally for anterograde ER-to-Golgi trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • GTP
  • protein
  • binding to ARL6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS