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FLASH GENE

Symbol

MYO18B

contributors: mct - updated : 23-08-2014

HGNC name	myosin XVIIIB
HGNC id	18150

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

KFS4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in lung and ovarian carcinoma tumoral     --low   by hypermethylation in ovarian cancer tumoral       loss of function in colorectal cancer tumoral   LOH     in lung cancer tumoral     --low   by promoter DNA methylation and histone deacetylation, was observed in 70p100 of lung cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

deficiency of Myo18B caused an embryonic lethality in mice accompanied by disruption of myofibrillar structures in cardiac myocytes at embryonic day 10.5