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FLASH GENE
Symbol MYO18B contributors: mct - updated : 23-08-2014
HGNC name myosin XVIIIB
HGNC id 18150
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a iq domain
  • a myosin head-like domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localized on the Z-lines of myofibrils in striated muscles
    • basic FUNCTION
  • may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm
  • a candidate tumor suppressor gene involved in carcinogenesis
  • unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HOMER2 (enhanced the ability of MYO18B to suppress the anchorage-independent growth of a lung cancer cell line)
  • interacts with the proteasomal subunit PSMC5 and is degraded by the ubiquitin-proteasome pathway
    • cell & other
    REGULATION
    induced by its expression was induced by myogenic differentiation through the binding of myocyte-specific enhancer factor-2 to its promoter
    ASSOCIATED DISORDERS
    corresponding disease(s) KFS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in lung and ovarian carcinoma
    tumoral     --low  
    by hypermethylation in ovarian cancer
    tumoral       loss of function
    in colorectal cancer
    tumoral   LOH    
    in lung cancer
    tumoral     --low  
    by promoter DNA methylation and histone deacetylation, was observed in 70p100 of lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    deficiency of Myo18B caused an embryonic lethality in mice accompanied by disruption of myofibrillar structures in cardiac myocytes at embryonic day 10.5