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FLASH GENE
Symbol SNW1 contributors: mct - updated : 02-03-2020
HGNC name SNW domain containing 1
HGNC id 16696
Location 14q24.3      Physical location : 78.183.945 - 78.227.497
Synonym name
  • nuclear receptor coactivator 62kDa
  • SKI interacting protein
  • homolog of Drosophila BX42
  • nuclear receptor coactivator NCoA-62
  • Synonym symbol(s) SKIP, NCOA-62, Bx42, PRPF45, Prp45, SKIIP, FUN20, MGC119379
    DNA
    TYPE functioning gene
    STRUCTURE 43.56 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2146 - 536 - 2006 16595688
    14 - 2209 - 571 - 2006 16595688
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SH2-like domain
  • a highly flexible region SKIPN, AAs 59-129 is intrinsically disordered, and upon binding to PPIL1, SKIPN undergoes a disorder-order transition , SKIP region of SNW1 interacted with the N-terminus of EFTUD2 as well as two independent regions in the C-terminus of SNRNP200
  • HOMOLOGY
    interspecies homolog to Drosophila bx42
    homolog to murine Skiip
    Homologene
    FAMILY SNW family
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocalized with PABP2
    basic FUNCTION
  • coactivator, enhancing transcription from some Pol II promoters (vitamine D, retinoid acid, estrogen and glucocorticoid-mediated gene expression)
  • binding PABP2 and directly controling the expression of muscle-specific genes at the transcriptional level
  • may be involved in oncogenesis
  • plays independent roles in transcription elongation and pre-mRNA splicing
  • modifying gene expression by both transcriptional activation and regulation of pre-mRNA splicing
  • acts with MYC and MEN1 to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress
  • recruits PPIL1 into the spliceosome by a region other than the peptidylprolyl isomerase active site
  • is a nuclear protein known to regulate gene expression
  • through its ability to regulate a specific domain of BMP activity in the vertebrate embryo, SNW1 is a critical regulator of neural plate border formation and thus neural crest specification
  • transcriptional cofactor distinct from other cofactors and involved in the regulation of many cancer-related proteins
  • spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in human cells
  • facilitates likely conformational rearrangements and/or contacts that couple U1 snRNP-recognition to downstream assembly events
  • novel transcriptional regulator of the NFKB1 pathway
  • WBP11 and SNW1 promote the removal of a specific subset of introns
  • CELLULAR PROCESS nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand-binding domain of the vitamine D receptor
  • retinoid receptors
  • poly (A)-binding protein 2 (PABP2)
  • FOXN3/SNW1 interaction indicates that FOXN3 binds to a region within the final 66 hydrophobic AAs of SNW1 (FOXN3 recruits SNW1 to repress genes important for tumorigenesis and the response to cancer treatments)
  • interacting with PPIL1 (PPIL1-SKIP complex acting during activation of the spliceosome, through PPIL1-binding fragment (PBF)
  • SKI (protooncogene)-(viral and cellular human)
  • MYOD
  • interacting with SMAD3
  • SNW1-associated factors DHX8 and PRPF19 are also selectively required for CDKN1A expression under stress
  • is a cofactor shown to interact with several nuclear receptor (NRs) and a diverse range of other transcription factors
  • interacts with AR in the nucleus and enhances AR-dependent transactivation and N/Cterminal-interaction supporting a role for SNW1 as an AR co-factor
  • SNW1 interacted with the N-terminus of EFTUD2 as well as two independent regions in the C-terminus of SNRNP200
  • ABL1 phosphorylates SKI-interacting protein (SNW1), a nuclear cofactor of the transcription factor SMAD3
  • SNW1 is indispensable for the transcriptional elongation of NFKB1 target genes such as the interleukin 8 (IL8) and TNF genes
  • SNW1 interacts with RBPJ to regulate the NOTCH signaling pathway
  • SNW1 interacts with WBP11 and is required for centriole biogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker could be a potential prognostic marker of hepatocellular carcinoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    could be a potential therapeutic target of hepatocellular carcinoma
    ANIMAL & CELL MODELS