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FLASH GENE
Symbol RTN4R contributors: mct/npt/pgu - updated : 17-03-2014
HGNC name reticulon 4 receptor
HGNC id 18601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-rich repeat (LRR)-type N-terminal domain,
  • a signal peptide
  • eight LRR domains,
  • a GPI anchorage site
  • a ligand binding domain
  • a cysteine-rich LRR-type carboxyl-terminal flanking domain (LRR-CT), a unique carboxyl-terminal region
    • HOMOLOGY
    interspecies ortholog to murine Nogo66R
    Homologene
    FAMILY
  • Nogo receptor family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • RTN4R staining was much stronger in the growth cone compared with the endoplasmic reticulum
    • basic FUNCTION
  • mediator of Nogo-66 (N terminal region of RTN4), inhibiting of axonal regeneration after nervous injury
  • mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system
  • having a function in maintaining neuronal survival that may be relevant for motor neuron development and degeneration
  • function as the ligand-binding component of a receptor complex that also includes LINGO1, NGFR or TNFRSF19
  • alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened
  • its regulation plays an important role in long-term memory formation
  • regulates formation of lasting memories
  • RTN4RL2 and RTN4R might be involved in the regulation of immune cell migration in the CNS
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex with RTN4 (play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in various lesions)
  • forms a ternary receptor complex with the leucine-rich repeat transmembrane protein LINGO1 and either the neurotrophin receptor NGFR or the orphan TNF receptor family member TNFRSF19
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OMG, RTN4 (to limit axonal regeneration after CNS injury)
  • NGFR binding, as a coreceptor (NGFR/RTN4R complex should involve, at least in embryonic and early postnatal life, the regulation of cell death)
  • MAG is a ligand for RTN4R and RTN4RL2
  • interaction between RTN4R and select members of the fibroblast growth factor (FGF) family, FGF1 and FGF2 binding directly and with high affinity to RTN4R (in primary cortical neurons, ectopic RTN4R inhibits FGF2-elicited axonal branching)
  • high affinity receptor for TNFSF13B
  • interactions of RTN4R with its co-receptors LINGO1, NGFR and the myelin inhibitor RTN4 is facilitated by gangliosides
  • CRTAC1 binds to RTN4R and functions as an endogenous RTN4R antagonist
  • OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
  • binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
  • post-transcriptional regulation of GABBR1, GABBR2 and KCNJ3 channels by RTN4R
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may be a prerequisite for establishment of enduring memories
    constitutional     --low  
    of RTN4RL2, and RTN4R promotes the adhesion of dendritic cells, interaction that could be important in neuroinflammatory disorders such as multiple sclerosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS