Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

RTN4R

contributors: mct/npt/pgu - updated : 17-03-2014

HGNC name	reticulon 4 receptor
HGNC id	18601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	26.88 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_023004 2 - 1924 NP_075380 - 473 - 2003 12839991

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex temporal cortex highly Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Homo sapiens Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a leucine-rich repeat (LRR)-type N-terminal domain,
	a signal peptide
	eight LRR domains,
	a GPI anchorage site
	a ligand binding domain
	a cysteine-rich LRR-type carboxyl-terminal flanking domain (LRR-CT), a unique carboxyl-terminal region

HOMOLOGY

interspecies

ortholog to murine Nogo66R

Homologene

FAMILY

Nogo receptor family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	RTN4R staining was much stronger in the growth cone compared with the endoplasmic reticulum

basic FUNCTION	mediator of Nogo-66 (N terminal region of RTN4), inhibiting of axonal regeneration after nervous injury
	mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system
	having a function in maintaining neuronal survival that may be relevant for motor neuron development and degeneration
	function as the ligand-binding component of a receptor complex that also includes LINGO1, NGFR or TNFRSF19
	alters the motility of immune cells exposed to myelin and may thus impact their behaviour within the CNS, particularly under conditions when immune cell activation is heightened
	its regulation plays an important role in long-term memory formation
	regulates formation of lasting memories
	RTN4RL2 and RTN4R might be involved in the regulation of immune cell migration in the CNS

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complex with RTN4 (play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in various lesions)
	forms a ternary receptor complex with the leucine-rich repeat transmembrane protein LINGO1 and either the neurotrophin receptor NGFR or the orphan TNF receptor family member TNFRSF19

INTERACTION

DNA

RNA

small molecule

protein	OMG, RTN4 (to limit axonal regeneration after CNS injury)
	NGFR binding, as a coreceptor (NGFR/RTN4R complex should involve, at least in embryonic and early postnatal life, the regulation of cell death)
	MAG is a ligand for RTN4R and RTN4RL2
	interaction between RTN4R and select members of the fibroblast growth factor (FGF) family, FGF1 and FGF2 binding directly and with high affinity to RTN4R (in primary cortical neurons, ectopic RTN4R inhibits FGF2-elicited axonal branching)
	high affinity receptor for TNFSF13B
	interactions of RTN4R with its co-receptors LINGO1, NGFR and the myelin inhibitor RTN4 is facilitated by gangliosides
	CRTAC1 binds to RTN4R and functions as an endogenous RTN4R antagonist
	OLFM1 is a novel RTN4R ligand that modulates the functions of the RTN4R complex in axonal growth
	binding of RTN4R and LINGO1 was similarly inhibited by OLFM1 coexpression
	post-transcriptional regulation of GABBR1, GABBR2 and KCNJ3 channels by RTN4R

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may be a prerequisite for establishment of enduring memories constitutional     --low   of RTN4RL2, and RTN4R promotes the adhesion of dendritic cells, interaction that could be important in neuroinflammatory disorders such as multiple sclerosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS