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FLASH GENE

Symbol

ZFHX4

contributors: mct - updated : 04-09-2020

HGNC name	zinc finger homeobox 4
HGNC id	30939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   inhibits the progression of esophageal squamous cell carcinoma

Susceptibility

to Orofacial clefts

Variant & Polymorphism other	de novo mutations in IRF6, TFAP2A, and ZFHX4 are associated with Orofacial clefts

Candidate gene	for congenital bilateral isolated ptosis (see PTOS1)
Marker	is a prognostic factor for ovarian serous cystadenocarcinoma (OSC)
Therapy target

ANIMAL & CELL MODELS