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FLASH GENE
Symbol ZFHX4 contributors: mct - updated : 04-09-2020
HGNC name zinc finger homeobox 4
HGNC id 30939
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger homeodomain
  • four homeodomains and 22 zinc fingers domains
    • HOMOLOGY
    interspecies homolog to to murine Zfhx4 (90 p100)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcription factor activity
  • involved in neural and muscle differentiation
  • is a crucial molecular regulator of tumor-initiating stem cell-like functions
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZFHX4 interacts with CHD4, a core member of the nucleosome remodeling and deacetylase (NuRD) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    inhibits the progression of esophageal squamous cell carcinoma
    Susceptibility to Orofacial clefts
    Variant & Polymorphism other
  • de novo mutations in IRF6, TFAP2A, and ZFHX4 are associated with Orofacial clefts
    • Candidate gene for congenital bilateral isolated ptosis (see PTOS1)
    Marker
  • is a prognostic factor for ovarian serous cystadenocarcinoma (OSC)
    • Therapy target
    ANIMAL & CELL MODELS