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FLASH GENE

Symbol

ZFHX4

contributors: mct - updated : 04-09-2020

HGNC name	zinc finger homeobox 4
HGNC id	30939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Hearing/Equilibrium ear       highly Nervous brain midbrain     predominantly Homo sapiens Fetal

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum skeletal   predominantly Homo sapiens Fetal Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	zinc finger homeodomain
	four homeodomains and 22 zinc fingers domains

HOMOLOGY

interspecies

homolog to to murine Zfhx4 (90 p100)

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcription factor activity
	involved in neural and muscle differentiation
	is a crucial molecular regulator of tumor-initiating stem cell-like functions

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ZFHX4 interacts with CHD4, a core member of the nucleosome remodeling and deacetylase (NuRD) complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   inhibits the progression of esophageal squamous cell carcinoma

Susceptibility

to Orofacial clefts

Variant & Polymorphism other	de novo mutations in IRF6, TFAP2A, and ZFHX4 are associated with Orofacial clefts

Candidate gene	for congenital bilateral isolated ptosis (see PTOS1)
Marker	is a prognostic factor for ovarian serous cystadenocarcinoma (OSC)
Therapy target

ANIMAL & CELL MODELS