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FLASH GENE
Symbol STEAP1 contributors: mct - updated : 04-06-2015
HGNC name six transmembrane epithelial antigen of the prostate 1
HGNC id 11378
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
six potential membrnae-spanning region flanked by hydrophilic N and C terminal domain
conjugated MetalloP
HOMOLOGY
interspecies homolog to murine Steap
Homologene
FAMILY
CATEGORY antigen , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • cell surface antigen significantly expressed at cell-cell junctions
  • STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism
    • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in prostate, bladder, colon, ovarian cancer, Ewing sarcoma
    tumoral     --over  
    in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma
    tumoral     --over  
    associated with poor overall survival in colorectal cancer, diffuse large B cell lymphoma, acute myeloid leukemia and multiple myeloma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is a potential therapeutic target for T-cell based immunotherapy or antibody therapy in a large panel of cancers
    ANIMAL & CELL MODELS