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FLASH GENE

Symbol

STEAP1

contributors: mct - updated : 04-06-2015

HGNC name	six transmembrane epithelial antigen of the prostate 1
HGNC id	11378

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q21      Physical location : 89.783.688 - 89.794.140
Synonym symbol(s)	PRSS24, STEAP

DNA

TYPE	functioning gene
STRUCTURE	10.00 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epithelial cell

cell lineage
cell lines	prostate tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six potential membrnae-spanning region flanked by hydrophilic N and C terminal domain

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to murine Steap

Homologene

FAMILY

CATEGORY

antigen , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cell surface antigen significantly expressed at cell-cell junctions
	STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism

CELLULAR PROCESS	cell life

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in prostate, bladder, colon, ovarian cancer, Ewing sarcoma tumoral     --over   in several types of human cancers, namely prostate, bladder, colon, pancreas, ovary, testis, breast, cervix, and Ewing sarcoma tumoral     --over   associated with poor overall survival in colorectal cancer, diffuse large B cell lymphoma, acute myeloid leukemia and multiple myeloma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     is a potential therapeutic target for T-cell based immunotherapy or antibody therapy in a large panel of cancers

ANIMAL & CELL MODELS