basic FUNCTION
| probable transcriptional activator in the premeiotic germ cells |
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playing an essential role in cardiac mesoderm specification |
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playing an important role for definitive hematopoiesis, and maintaining fetal but not adult hematopoietic stem cells |
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required for hematopoiesis in the fetal liver and yolk sac |
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playing an important roles in controlling both oligodendrocyte progenitor cell cycle exit and differentiation |
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potent activator of Fgf-3 transcription |
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involved in the regulation of parietal endoderm-specific enhancer activity of the mouse Lama1 gene |
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involved in mammalian vascular development |
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an essential role in cardiac muscle cell formation |
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Sry-related HMG-box transcription factor developmentally expressed in both the definitive endoderm and extraembryonic endoderm |
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regulates endodermal lineage commitment and is thought to function antagonistically to the pluripotency determinant SOX2 |
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required for early endoderm formation, and activates the cell cycle and reinitiates multipotent progenitor cell behavior in mature lung cells |
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required for diverse developmental processes including endoderm formation, vascular development, and fetal hematopoietic stem cell maintenance |
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a strain-specific modifier of the Sox18 mutant phenotype |
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role of SOX17 and HES1 in patterning and morphogenetic segregation of ventral foregut lineages |
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transcriptional regulator of differentiation in embryonic pluripotent cells |
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can directly regulate Wnt/beta-catenin-dependent transcription of the LEF1 promoter |
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role of SOX17 in kidney and urinary tract development |
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regulates the Wnt/CTNNB signaling pathway in oligodendrocyte progenitor cells |
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sufficient to confer fetal hematopoietic stem cells characteristics to adult hematopoietic progenitors and is therefore a key determinant of fetal hematopoietic stem cells identity |
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suppresses cyclin D1 expression and cell proliferation by directly antagonizing & |
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946;-catenin |
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is a transcription factor that can inhibit Wnt signaling, promote the degradation of activated CTNNB1, and participate in cell proliferation |