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FLASH GENE
Symbol HMX2 contributors: mct/npt - updated : 11-04-2008
HGNC name H6 family homeobox 2
HGNC id 5018
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • HMX homeobox family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating gene expression, morphogenesis and differentiation
  • may be functioning redundantly to control embryonic development of the central nervous system
  • have a role in sensorineural hearing (Miller 2009)
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis and embryogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for human inner ear vestibular development and a role in sensorineural hearing observed in del 10q26 patients (Miller 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hmx2/hmx3 knockout mice have vestibular anomalies