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FLASH GENE
Symbol HMX2 contributors: mct/npt - updated : 11-04-2008
HGNC name H6 family homeobox 2
HGNC id 5018
Location 10q26.13      Physical location : 124.907.637 - 124.910.188
Synonym name
  • homeobox gene H6-like
  • homeo box (H6 family) 2
    • Synonym symbol(s) H6L, NKX5-2
    DNA
    TYPE functioning gene
    STRUCTURE 2.55 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1628 - 273 - Stadler (1995)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • HMX homeobox family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating gene expression, morphogenesis and differentiation
  • may be functioning redundantly to control embryonic development of the central nervous system
  • have a role in sensorineural hearing (Miller 2009)
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text morphogenesis and embryogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for human inner ear vestibular development and a role in sensorineural hearing observed in del 10q26 patients (Miller 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hmx2/hmx3 knockout mice have vestibular anomalies