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FLASH GENE
Symbol ACADVL contributors: mct - updated : 02-01-2023
HGNC name acyl-Coenzyme A dehydrogenase, very long chain
HGNC id 92
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an all-alpha all terminal domain, transmembrane segment
  • all-alpha, four helical up-and-down bundle
  • C terminal domain
    • mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Acadvl
    Homologene
    FAMILY acyl-CoA dehydrogenase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acyl-CoA dehydrogenase, very long chain 14 to 20C, first step of the fatty acid beta-oxidation
  • transferring an electron to ETF
  • importance of ACADVL in Acute myeloid leukemia (AML) cell biology
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD+
    protein
    cell & other
    REGULATION
    activated by activator protein 2 (TAFP2A)
    ASSOCIATED DISORDERS
    corresponding disease(s) VLCADD
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in recurrent pregnancy loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS