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FLASH GENE

Symbol

ACADVL

contributors: mct - updated : 02-01-2023

HGNC name	acyl-Coenzyme A dehydrogenase, very long chain
HGNC id	92

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000018 20 - 2184 NP_000009 70.4 655 - 1995 7668252 NM_001033859 19 - 2118 NP_001029031 - 633 - 1995 7668252 NM_001270447 21 - 2227 NP_001257376 - 678 - 1995 7668252 NM_001270448 19 - 2259 NP_001257377 - 579 - 1995 7668252

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart           vessel         Digestive liver       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual photoreceptor layer   Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	developing kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an all-alpha all terminal domain, transmembrane segment
	all-alpha, four helical up-and-down bundle
	C terminal domain

mono polymer

homomer , dimer

isoforms

Precursor

HOMOLOGY

interspecies

ortholog to murine Acadvl

Homologene

FAMILY

acyl-CoA dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus,nucleoplasm

basic FUNCTION	acyl-CoA dehydrogenase, very long chain 14 to 20C, first step of the fatty acid beta-oxidation
	transferring an electron to ETF
	importance of ACADVL in Acute myeloid leukemia (AML) cell biology

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

energetic , lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD+

protein

cell & other

REGULATION

activated by

activator protein 2 (TAFP2A)

ASSOCIATED DISORDERS

corresponding disease(s)

VLCADD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in recurrent pregnancy loss

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS