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FLASH GENE
Symbol CNKSR2 contributors: - updated : 13-04-2006
HGNC name connector enhancer of kinase suppressor of Ras 2
HGNC id 19701
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately
 brainhindbraincerebellum moderately
 brainbasal nucleicaudate nucleus moderately
 braindiencephalonhypothalamus moderately
 braindiencephalonamygdala moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PH domain
  • STAR (sterile alpha motif) domain
  • PDZ domain
    • HOMOLOGY
    interspecies homolog to Drosophila kinase suppressor of RAS
    homolog to rattus Maguin 1,membrane associated GUK interacting protein
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text cell junction
    basic FUNCTION regulator of signaling
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    RAS/MAPK signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting and targeting with RAF to specific subcellular compartments upon RAS activation
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS