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FLASH GENE

Symbol

APOBEC3B

contributors: mct - updated : 15-11-2015

HGNC name	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
HGNC id	17352

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chondrosarcoma tumoral     --over   in the majority of ovarian cancer cell lines constitutional   deletion     loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a marker of pure prognosis and poor outcomes for ER&
	8201;+&
	8201;breast cancer, suggesting that genetic aberrations induced by APOBEC3B contribute to breast cancer progression
Therapy target
	System Type Disorder Pubmed cancer bone   APOBEC3B knockdown may be a useful therapy to enhance apoptosis in chondrosarcoma cancer hemopathy   candidate gene eliciting an effective immune response against mantle cell lymphoma

ANIMAL & CELL MODELS