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FLASH GENE

Symbol

APOBEC3B

contributors: mct - updated : 15-11-2015

HGNC name	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
HGNC id	17352

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	10.38 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004900 8 - 1536 NP_004891 - 382 - 2006 17020885 NM_001270411 8 - 1485 NP_001257340 - 357 - 2006 17020885

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Hearing/Equilibrium ear       highly Lymphoid/Immune spleen       highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines	colorectal adenocarcinoma cells and chronic myelogenous leukemia cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one active site and a duplicated active site
	two AA insert in the PCXXC region
	two cytidine deaminase domains (CDD)( both active sites are required for antiviral function but serve separate functions)

conjugated

LipoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Aid

intraspecies

homolog to APOBEC1

Homologene

FAMILY

cytidine and deoxycytidylate deaminase family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	AA 18, 19, 22, and 24 were the major determinants for nuclear versus cytoplasmic localization and antiretroviral activity

basic FUNCTION	may be RNA editing enzymes and have roles in growth or cell cycle control
	having a function to neutralize specific lentiviruses
	may potentially contribute to the cytosine mutation clusters observed in many cancers
	appears to restrict engineered L1 retrotransposition in a broad range of cell types, including pluripotent cells
	APOBEC3B and AICDA have similar nuclear import mechanisms
	aberrant expression of APOBEC3B can evoke genomic instability by inducing base substitutions into human genome, which might lead to tumorigenesis in human cells
	role in innate immune responses, and source of mutation in cervical, bladder, lung, head and neck, and breast cancers
	APOBEC3A- and APOBEC3B-induced mutagenesis primarily results from the deamination of the lagging strand template during DNA replication
	APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with APOBEC3G

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chondrosarcoma tumoral     --over   in the majority of ovarian cancer cell lines constitutional   deletion     loss of APOBEC3B may increase host susceptibility to HIV-1 acquisition and progression to AIDS

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a marker of pure prognosis and poor outcomes for ER&
	8201;+&
	8201;breast cancer, suggesting that genetic aberrations induced by APOBEC3B contribute to breast cancer progression
Therapy target
	System Type Disorder Pubmed cancer bone   APOBEC3B knockdown may be a useful therapy to enhance apoptosis in chondrosarcoma cancer hemopathy   candidate gene eliciting an effective immune response against mantle cell lymphoma

ANIMAL & CELL MODELS