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FLASH GENE
Symbol TMC2 contributors: mct - updated : 12-12-2017
HGNC name transmembrane channel-like 2
HGNC id 16527
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text cochlea,placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Tmc2
ortholog to zebrafish Tmc2a
intraspecies homolog to TMC1
Homologene
FAMILY
  • TMC family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be crucial for normal auditory function
  • LHFPL5, TMIE, TMC1, and TMC2 have so far been linked to the transduction channel
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCDH15 interacts with transmembrane channel-like proteins TMC1 and TMC2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS