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FLASH GENE

Symbol

TMC2

contributors: mct - updated : 12-12-2017

HGNC name	transmembrane channel-like 2
HGNC id	16527

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	105.18 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080751 20 - 3169 NP_542789 - 906 - Kurima (2003)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     lowly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	cochlea,placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Tmc2
	ortholog to zebrafish Tmc2a

intraspecies

homolog to TMC1

Homologene

FAMILY

TMC family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be crucial for normal auditory function
	LHFPL5, TMIE, TMC1, and TMC2 have so far been linked to the transduction channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PCDH15 interacts with transmembrane channel-like proteins TMC1 and TMC2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS