| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
in non small cell lung carcinoma (with poor differentiation), in cervical cancer (promoter was methylated in cervical cancer)  |
| tumoral
|
|
| --low
|
|
|
in kidney, urinary bladder, liver, prostate, pancreas cancers |
| tumoral
|
|
| --low
|
|
|
resulting in impairment of glandular structure and uncontrolled prostate epithelial cell (PrEC) proliferation, both of which are crucial for prostate cancer progression |
| tumoral
|
|
| --over
|
|
|
induces cancer cell apoptosis through endoplasmic reticulum (ER) stress |
| tumoral
|
|
| --low
|
|
|
in all of the seminoma and non-seminomatous germ cell tumor tissues |
| tumoral
|
|
| --over
|
|
|
strongly expressed in ganglioneuroma but only weakly in neuroblastoma |
| tumoral
|
|
| --low
|
|
|
by promoter methylation in breast cancer, and proves as a novel prognostic marker potentially useful in the clinical management of this disease |
| tumoral
|
|
| --over
|
|
|
in hepatoblastomas and hepatocellular carcinomas |
| tumoral
|
|
| --low
|
|
|
in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative disease |
