Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL17F contributors: mct/npt - updated : 28-06-2008
HGNC name interleukin 17F
HGNC id 16404
Location 6p12.2      Physical location : 52.101.483 - 52.109.298
Synonym name cytokine ML-1
Synonym symbol(s) ML1, IL-17F, ML-1, IL24
DNA
TYPE functioning gene
STRUCTURE 7.82 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389397 6 hypothetical gene supported by BC000383; BC004432; NM_152857 LOC391926 6 similar to 40S ribosomal protein S15a PKHD1 6p12.2 polycystic kidney and hepatic disease 1 (autosomal recessive) IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase LOC391928 6 similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) GSTA2 6p12.2 glutathione S-transferase A2 LOC391929 6 similar to glutathione transferase (EC 2.5.1.18) alpha-3 [similarity] - human GSTA1 6p12.2 glutathione S-transferase A1 GSTAP1 6p12.2 glutathione S-transferase A pseudogene 1 GSTA5 6p12.1 glutathione S-transferase A5 FLJ32293 6p12.3 hypothetical protein FLJ32293 GSTA3 6p12 glutathione S-transferase A3 GSTA4 6p12 glutathione S-transferase A4 RN7SK 6pter-p25 RNA, 7SK, nuclear ICK 6p12.3-p11.2 intestinal cell (MAK-like) kinase FBXO9 6p12.3-p11.2 F-box only protein 9 GCM1 6p21-p12 glial cells missing homolog 1 (Drosophila) LOC389398 6 LOC389398 ELOVL5 6p21.1-p12.1 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 808 - 163 - Seiderer (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • IL17F family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating cartilage matrix turnover, stimulating T cell proliferation and inhibiting angiogenesis
  • potent inducer of CXCR3 in bronchial epithelial cells, having a regulatory role in airway inflammation
  • inducing in a time-dependent fashion the expression of IL6 and IL8 in both primary bronchial epithelial cells (PBECs) and human umbilical vein endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand if IL17RC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Crohn disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target IL17F-CXCR3 axis might be a novel and critical therapeutic target for airway inflammatory diseases
    ANIMAL & CELL MODELS